Web反应实例. ⼀、TMSOTf中性条件下脱Boc⽰例. To a solution containing 2 (1.0 g, 3.9 mmol) in 30 mL of dry CH2Cl2was slowly added TBDMSOTf (0.9 mL, 4.1 mmol). After stirring the reactionmixture for 6 h, the solvent was evaporated, and the crude product (0.8 g, 75%) was obtaineded, which was used directly inthe next step. ⼆、 TMSOTf ... WebDec 5, 2008 · Abstract: Fast, efficient and selective deprotection of the tert -butoxycarbonyl (Boc) group of various amino acids and peptides was achieved by using hydrogen …

tert-Butyloxycarbonyl protecting group - Wikipedia

WebTraditional approaches for N-Boc deprotection relies largely on TFA-induced cleavage.14 Other strategies reported for the deprotection of N-Boc include the use of metal … WebH-Lys(Boc)-OH ≥95%; CAS Number: 2418-95-3; Synonyms: Nε-Boc-L-リジン; Linear Formula: (CH3)3COCONH(CH2)4CH(NH2)COOH; find Sigma-Aldrich-359661 MSDS, … helix test case management

Boc Protection - Common Conditions - Common Organic Chemistry

WebFast, efficient and selective deprotection of the tert-butoxycarbonyl (Boc) group of various amino acids and peptides was achieved by using hydrogen chloride (4 m) in anhydrous dioxane solution for 30 min at room temperature. In the cases studied in our laboratory, this protocol provided superior se … WebLewis acids. Thermal. Enzymes. The BOC group is generally one of the most sensitive to acids, so often selective deprotection in the presence of other acid sensitive groups is … http://commonorganicchemistry.com/Rxn_Pages/Boc_Protection/Boc_Protection_HCl.htm helix terminal editor