Cisplatin lung toxicity

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August undefined, 2024

WebSep 15, 2024 · Cisplatin is mutagenic, teratogenic and carcinogenic and its use has been show to increase the risk of secondary malignancies, particularly leukemia. … WebThis suggests that cisplatin-induced lung damage can damage the cilia, manifesting as increased ciliary proteins in the BALF. By increasing oxidative stress in the lung, …

Oral vinorelbine and cisplatin with concurrent radiotherapy after ...

WebOct 5, 2014 · Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers … WebAdverse effects of RT-CT were grades 3 to 4 neutropenia (four patients) and grade 3 esophageal toxicity (one patient). No treatment-related deaths occurred. Conclusion: The oral vinorelbine-cisplatin combination with concurrent RT is feasible and has a favorable risk-benefit ratio in stage IIIA/IIIB NSCLC. Publication types northeastern chicago

Clinical comparative investigation of efficacy and toxicity of ...

WebThe combination of both TAS and its monomers with cisplatin can reduce toxicity and increase effectiveness, which reveals the new role of TAS as a potential anticancer drug in NSCLC treatment. ... Stephania tetrandra and ginseng-containing chinese herbal formulation NSENL reverses cisplatin resistance in lung cancer xenografts. Am. J. Chin. Med ... WebDec 7, 2024 · In the present study, the carboplatin-containing regimen was associated with a higher incidence of thyroid and pulmonary toxicity. Therefore, for patients with co … WebSep 4, 2013 · Short hydration is safe and reduces the frequency of severe renal toxicities in regimens containing cisplatin (≥75 mg/m 2) for the treatment of patients with lung cancer. Cisplatin labels with regard to hydration should accept short- and lower-volume hydration as an option based on the result of the present study. Funding how to restore icloud messages

Total alkaloids in Stephania tetrandra induce apoptosis by …

WebJun 1, 2013 · It has been shown that cisplatin administration induced a large amount of NO, which may lead to a greater formation of ROS and RNS causing cellular damage (Chirino et al., 2004, Demkow et al., 2011). A toxic role for nitric oxide itself or by generation of nitrosative stress has also been described. WebChemotherapy-related cardiac toxicity is a rare but serious adverse event in patients with cancer. Thus far, no case of serious cardiac toxicity of pemetrexed has been reported. We describe the case of a patient with advanced lung cancer and cardiomyopathy due to … northeastern child care services scranton paWebFeb 22, 2024 · Lung cancer is the leading cause of cancer-related death in the Unites States, and approximately 85% of all lung cancers are classified as non-small cell lung … northeastern chimney

"WebFeb 22, 2016 · In patients treated for disseminated testicular cancer with bleomycin, etoposide, and cisplatin (BEP), the risk of acute bleomycin-induced changes is ≤ 6.8%, with a 0% to 1% risk of death. 1 - 4 Serious long-term toxicity has been indicated with an increased risk of late mortality caused by pulmonary diseases. 5 These findings were … " - Cisplatin lung toxicity

Cisplatin lung toxicity

Clinical comparative investigation of efficacy and toxicity of ...

WebNov 12, 2024 · Commonly reported side effects of cisplatin include: bone marrow depression, nephrotoxicity, and ototoxicity. Continue reading for a comprehensive list of … WebCisplatin, first (platinum) compound to be evolved as an anticancer agent, has found its important place in cancer chemotherapy. However, the dose-dependent toxicities of cisplatin, namely...

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WebPulmonary toxicity of cytotoxic agents Platinum compounds The administration of cisplatin and carboplatin, the 2 most commonly used platinum derivative agents, can lead to … WebNov 26, 2024 · Cisplatin-Induced Toxicity . Cisplatin, cis- diamine-dichloro-platinum (CDDP) is one of the most used chemotherapy drugs because it is effective against different types of tumors. ... Mediators such as 4-HNE and H 2 O 2 are among the most relevant secondary messengers induced by ozone during lung toxicity following airway …

WebMar 22, 2024 · Pulmonary toxicities occur in 10% of treated patients. In approximately 1%, the nonspecific pneumonitis induced by Bleomycin progresses to pulmonary fibrosis and death. Although this is age and … WebDec 1, 2024 · Dose adjustments for both docetaxel and cisplatin were performed according to pre-defined criteria for each type of toxicity (mainly grade 4 neutropenia and grade 3–4 neuropathy). Two dose reductions were allowed for DC75 (first to 60 mg/m 2, second to 50 mg/m 2), but only 1 reduction was allowed for DC60 and DCM therapy (to 50 mg/m 2). …

Webcancer with Cisplatin is 95% with a 25 year risk of cardiovascular toxicity in 16% patients due to direct endothelial damage of Cisplatin or indirectly induced hormonal and … WebThus, the SNP rs10505477 in CASC8 may serve as an underlying risk marker for detecting and diagnosing lung cancer, and could be used to determine the response and toxicity of platinum-based chemotherapy in lung cancer patients. However, further larger well-designed studies will be needed to clarify the biological and clinical significance of ...

WebCisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose limiting.

WebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... Targeted therapy for cisplatin-resistant lung cancer via aptamer-guided nano-zinc carriers containing USP14 siRNA. Xinmin Zhao, ... Some chronic toxicity was observed in the 10 mg ... northeastern chiropracticWebCisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung cancer, head and neck cancer, mesothelioma, ovarian cancer, and bladder cancer. It is also used prior to bone marrow and stem cell transplantation. northeastern chimney selkirk nyWebThe TPF triplet regimen (docetaxel, cisplatin, and 5‐FU) has a trend of further improving treatment efficacy compared with the traditional doublet regimen. 35 , 36 In a phase II study, concurrent chemoradiotherapy with TPF achieved a clinical CR rate of 52.4%, much higher than the previously reported CR rate of 20%. 9 However, the high ... north eastern circuit ethics courseWebDec 7, 2024 · The EC regimen was associated with a higher risk of grade 1–2 haematological toxicities, including anaemia, thrombocytopaenia, hypothyroidism, dyspnoea, infection, hypertension and arrythmia (all p < 0.001), hyponatremia ( p = 0.022) and pneumonia ( p = 0.013), whereas patients who underwent the EP regimen were more … northeastern chiropractic framingham maWebJan 23, 2024 · The major toxicities occur in the lung and skin, where the drug is concentrated. Up to 20% of patients treated with bleomycin develop clinical pulmonary … how to restore incomplete iphone backupWebFeb 22, 2024 · Lung cancer is the leading cause of cancer-related death in the Unites States, and approximately 85% of all lung cancers are classified as non-small cell lung cancer (NSCLC), which is extremely difficult to treat and its survival rate is low. After decades of clinical trials, the most effective treatments are still those that implement the … northeastern cioWebClinical Comparative Investigation of Efficacy and Toxicity of Cisplatin plus Clinical comparative investigation of efficacy and toxicity of cisplatin plus gemcitabine or plus Abraxane as first-line chemotherapy for stage III/IV non-small-cell lung cancer Dan Ai,1,2 Yan Guan,2 Xiu-Ju Liu,2 Chu-Feng Zhang,1,2 Peng Wang,1,2 Hong-Lu Liang,1,2 Qi … how to restore icloud to iphone