Fosphenytoin maintenance dose
WebNov 8, 2024 · The recommended dose in adults is a loading dose of 10 to 20 phenytoin sodium equivalents per kilogram intravenously initially, and then a maintenance dose of 4 to 6 equivalents per kilogram each day in … WebTwo studies have examined the safety and efficacy of phenytoin oral loading doses. 6, 7 In both studies, single oral phenytoin doses of 15-20 mg/kg provided therapeutic …
Fosphenytoin maintenance dose
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WebFosphenytoin None - see Chart A PB None - see Chart A N/A LCM or FOS N/A LCM or FOS None - see Chart A N/A ... A loading dose is not necessary in all cases, but may be considered in patients with frequent seizures, or as otherwise clinically indicated. ... Maintenance 4-6 mg PE/kg/day (divided q12h) 200-600 mg/day (divided q12h) 1000 … WebOct 14, 2012 · Fosphenytoin is a phosphate ester prodrug developed as an alternative to intravenous phenytoin for acute treatment of seizures. Advantages include more convenient and rapid intravenous administration, availability for intramuscular injection, and low potential for adverse local reactions at injection sites. Drawbacks include the occurrence …
WebFosphenytoin is administered at 15-20 mg PE/kg when patients are given a loading dose and 4-7 mg PE/kg for maintenance doses. Patients may respond differently due to … WebApr 15, 2024 · Maintenance dose: 4-6 mg PE/kg/day IV in divided doses IV, not to exceed 150 mg PE/min Pediatric dosage Children between birth to 17 years (Cerebyx, generic): Loading dose: 10-15 mg PE/kg IV; 1-2 PE/kg/min, or 150 mg PE/min, whichever is slower Maintenance dose 2-4 mg PE/kg/day IV in every 12 hours divided doses initially, THEN
WebIM or IN 0.2 mg/kg Maximum 10 mg/dose IV OR IO 0.1 mg/kg Maximum 5 mg/dose Repeat as needed every 3-5 minutes if seizure continues General Principles 1. ... Consider maintenance Fosphenytoin: 5mg/kg/d ÷q8 hr or Phenobarbital 3-5 mg/kg/d 1. ndLOAD with a 2 medication a. Levetiracetam 40-60 mg/kg (Max 4500 mg) OR b. Fosphenytoin … WebJul 4, 2024 · The loading dose should be followed by maintenance doses of either fosphenytoin sodium injection or phenytoin [see Dosage and Administration (2.4)]. If …
WebAug 25, 2024 · A fosphenytoin maintenance dose is most efficacious when started 12 hours following the loading dose in pediatric patients with status epilepticus or seizure clusters. The maintenance dose...
WebJan 9, 2015 · Give sequential small doses of rapidly acting, short-duration benzodiazepine (e.g., midazolam at 1mg/dose), or a nonsedating IV anticonvulsant (e.g., levetiracetam, valproic acid, fosphenytoin, or lacosamide). Between doses, repeat clinical & EEG assessment. Trial is stopped for any of the following: sketchup university loginWebSep 3, 2024 · Maintenance dose: 4 to 6 mg PE/kg/day. Fosphenytoin offers many advantages over phenytoin: minimum phlebitis, complete IM absorption, and the ability to … swaffham saturday auctionWebNov 3, 2024 · SESQUIENT (or phenytoin) doses are usually selected to attain therapeutic serum total phenytoin concentrations of 10 to 20 mcg/mL (unbound phenytoin concentrations of 1 to 2 mcg/mL). Following SESQUIENT administration, it is recommended that phenytoin concentrations not be monitored until conversion to phenytoin is … sketchup university licenseWebNonemergent initial maintenance dose (initiated 12 hr after loading dose): 4–6 mg PE/kg/24 hr IV/IM ÷ Q12–24 hr. View chapter on ClinicalKey. ... Fosphenytoin is administered in phenytoin equivalents (PE). The usual loading dose of fosphenytoin is 15-20 PE/kg administered over 30 min. Maintenance doses of 4-8 PE/kg/day can be given. … swaffham sacred heart schoolWebJan 1, 2024 · The ED physician ordered the correct loading dose of intravenous (IV) phenytoin, to be administered every 8 hours for 3 doses. Unfortunately, the physician failed to order that the dose be switched back to the appropriate maintenance dose of once daily after the loading was completed, so the patient continued to receive IV phenytoin every … swaffham rugby club fireworksWebMaintenance dose: 4-6 mg PE/kg/day IV in divided doses IV, not to exceed 150 mg PE/min Individualize subsequent maintenance doses by monitoring serum concentrations to … swaffham shoppingWebMaintenance: Initially, 4-5 mg/kg daily in 1-4 divided doses by IV infusion at a rate of 1-2 mg/kg/min; max rate: 2 mg/kg/min or 100 mg/min (whichever is slower); to be started at the next identified dosing interval. Subsequent doses are adjusted based on patient response and trough plasma-phenytoin levels. sketchup university of guelph