Web1 jan. 2006 · The new genus Henipavirus was created within the Paramyxovirinae subfamily of the Paramyxoviridae for the Biosafety Level 4 (BSL4) pathogens Hendra … Web22 jul. 2010 · For many (+)RNA viruses, RNA replication requires viral enzymes such as RdRp, helicase, capping enzymes, and NTPase, as well as non-enzymatic proteins …

Detailed morphological characterisation of Hendra virus infection …

Web12 nov. 2010 · To circumvent this problem, we have developed a henipavirus envelope glycoprotein pseudotyped lentivirus assay system using either a luciferase gene or green … Web20 mei 2016 · Furthermore, to facilitate spatiotemporal studies on henipavirus pathogenesis, we generated a Firefly luciferase-expressing NiV and monitored virus … one in the chamber gun

A single dose investigational subunit vaccine for human use …

Web15 mei 2024 · Favipiravir inhibits henipavirus replication in vitro. To determine the inhibitory potential of favipiravir on NiV and HeV replication in vitro, we employed a virus … Upon virus entry into the cell, RNA replication can occur. As a negative-strand RNA virus, GhV brings its own RNA-dependent RNA-polymerase with it into the cell. Three proteins are essential for GhV replication: The nucleocapsid protein (N), the phosphoprotein (P), and the RNA-dependent RNA polymerase (RdRp) (L). It has been shown that GhV and other Henipavirus's RdRp's have a two-fold function, RNA transcription to mRNA and RNA replication of the genom… Web21 mrt. 2024 · Identification and validation of virus and/or host targets necessary for henipavirus replication that could serve as starting points for therapeutic discovery. Inhibitors of virus and/or host targets that are broadly active across paramyxoviruses with a preference for henipaviruses. is bellville cape town safe